Nephrolithiasis is a condition frequently observed in felines, with or without concomitant chronic kidney disease. About 90% of nephrolites are composed of calcium oxalate, which cannot dissolve. There are functional foods known as nutraceuticals which provide health benefits such as renoprotection. Due to these benefits and the high prevalence of nephrolithiasis in feline species, the present study aimed to evaluate the efficacy of the association of some nutraceuticals in the dissolution of nephrolites. We separated 51 cats with nephrolithiasis into 2 groups: control (n = 12) and study (n = 39). The control group (CG) received a placebo and the study group (SG), nutraceuticals (magnesium chelate, resveratrol, vitamin K2, docosahexaenoic acid, and eicosapentaenoic acid). Laboratory tests (blood and urine) and ultrasound abdominal were performed at day 0 and 30 days after enrollment. Monitoring the therapeutic efficacy in both groups was performed on day 30 for the CG and on days 30, 60, and 90 for the SG. The CG cats, after this step, were referred to surgery or to the SG. The diameter of nephrolites was significantly different before and after treatment, indicating a reduction in nephroliths over time. The dissolution of nephrolites was correlated with the synergism promoted by the combination of nutraceuticals and not with the individual beneficial action of each nutraceutical. The undissolved nephrolites were attributed to the nephrolites that obtained partial dissolution at the end of 90 days, in that they possibly needed a longer time to obtain complete dissolution or that they present another mineral composition in their nucleus; it is a compound-type urolith. The nutraceutical compound proved to be effective in the dissolution of nephrolites and the time of use (up to 90 days) showed no negative influence on the clinical or laboratory tests during the treatment.

Rosemar Freitas completed her PHD at the age of 42 years from Federal Rural University of Rio de Janeiro, UFRRJ, Brazil. She has Residency in Internal Medicine Clinic at the Federal Rural University of Rio de Janeiro, UFRRJ, Brazil. She won the XIV Professor Carlos Maria Antônio Hubinger Tokarnia Research Prize - Staging of chronic kidney disease in domestic dogs (Canis familiaris, LINNAEUS, 1758) with chronic valve disease, Federal Rural University of Rio de Janeiro - UFRRJ. It was your master's thesis. She also specializes in Veterinary Urology and Nephrology. She has 9 published scientific articles. a chapter of a book entitled "Disorders of the Cardiovascular-renal Axis in cats". was a university professor in the discipline of clinical medicine for companion animals.